430 research outputs found
The Collective Object: Realizing Collective Space in an Era of Bigness
Architecture reacted to the Technological Revolution of the late 19th century with inspired proposals of optimistic expectation for the new era. The advancements of elevators, escalators and air conditioning meant almost limitless potential for the scale and scope of the built environment. However, society quickly realized the advantageous reality of this technology: Their buildings no longer needed the cities which surrounded them.
Endless interiors and âcities-within-citiesâ meant the possibility of a lifestyle where people could choose to never again interact with the undesirables of the true city. The built environment actively resisted the collective. A trend of self-interested architectures affected urban societies with a cultural shift towards the exclusion that their cities embodied. This phenomenon, termed âBignessâ by Rem Koolhaas, is also linked to his essay, âAtlantaâ, where he critiqued John Portmanâs network of sky bridges for producing this supremacist phenomenon and suggested Atlanta as âthe real city at the end of the 20th centuryâ.
By studying the evolution and devolution of the collective objects which once gathered the masses of society, this research seeks to understand how the loss of these spaces links to shifts in cultural values throughout history. This leads to an awareness of how âBignessâ affects a disposition of exclusion in contemporary culture. This thesis proposes to revitalize the gathering potentials of the city to create a culture of inclusion through the design of a new collective object in an era of architectural âbignessâ
Image-based Quantification of 3D Morphology for Bifurcations in the Left Coronary Artery: Application to Stent Design
Background
Improved strategies for stentâbased treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology. Objective
We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations. Methods
Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including crossâsectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using openâsources software and custom applications. Geometric characterization was performed by comparison of means, correlation, and linear discriminant analysis (LDA). Results
Differences between metrics suggest dedicated or multistent approaches should be tailored for each bifurcation. For example, the side branch of the LCX (i.e., obtuse marginal; OM) was longer than that of the LMCA (i.e., LCXprox) and LAD (i.e., first diagonal; D1). Bifurcation metrics for some locations (e.g., LMCA Finet ratio) provide results and confidence intervals agreeing with prior findings, while revised metric values are presented for others (e.g., LAD and LCX). LDA revealed several metrics that differentiate between artery locations (e.g., LMCA vs. D1, LMCA vs. OM, LADprox vs. D1, and LCXprox vs. D1). Conclusions
These results provide a foundation for elucidating common parameters from healthy coronary arteries and could be leveraged in the future for treating diseased arteries. Collectively the current results may ultimately be used for design iterations that improve outcomes following implantation of future dedicated bifurcation stents
The ACS Virgo Cluster Survey IV: Data Reduction Procedures for Surface Brightness Fluctuation Measurements with the Advanced Camera for Surveys
The Advanced Camera for Surveys (ACS) Virgo Cluster Survey is a large program
to image 100 early-type Virgo galaxies using the F475W and F850LP bandpasses of
the Wide Field Channel of the ACS instrument on the Hubble Space Telescope
(HST). The scientific goals of this survey include an exploration of the
three-dimensional structure of the Virgo Cluster and a critical examination of
the usefulness of the globular cluster luminosity function as a distance
indicator. Both of these issues require accurate distances for the full sample
of 100 program galaxies. In this paper, we describe our data reduction
procedures and examine the feasibility of accurate distance measurements using
the method of surface brightness fluctuations (SBF) applied to the ACS Virgo
Cluster Survey F850LP imaging. The ACS exhibits significant geometrical
distortions due to its off-axis location in the HST focal plane; correcting for
these distortions by resampling the pixel values onto an undistorted frame
results in pixel correlations that depend on the nature of the interpolation
kernel used for the resampling. This poses a major challenge for the SBF
technique, which normally assumes a flat power spectrum for the noise. We
investigate a number of different interpolation kernels and show through an
analysis of simulated galaxy images having realistic noise properties that it
is possible, depending on the kernel, to measure SBF distances using
distortion-corrected ACS images without introducing significant additional
error from the resampling. We conclude by showing examples of real image power
spectra from our survey.Comment: ApJS, in press, complete version of the paper at the link:
http://www.physics.rutgers.edu/~pcote/acs/publications.htm
Addressing the Supportive Transportation Challenges of Community-Residing Older Adults
The ability to get to where you want to go, when you want to go there is a key factor for aging-in-place in our communities. It is often taken for granted until that ability is compromised. The informal network of family and friends, if it exists, is not likely to be a sustainable transportation alternative for persons with cognitive impairment or for older adults with limitations that may not fit eligibility criteria for senior transportation services, where they exist. The purpose of this study was to investigate the potential of communities to address the specialized supportive mobility needs of community-residing older adults. A major conclusion to emerge from the research is the connection of mobility to healthcare
Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes
Massive palindromes in the human Y chromosome harbor mirror-image gene pairs essential for spermatogenesis. During evolution, these gene pairs have been maintained by intrapalindrome, arm-to-arm recombination. The mechanism of intrapalindrome recombination and risk of harmful effects are unknown. We report 51 patients with isodicentric Y (idicY) chromosomes formed by homologous crossing over between opposing arms of palindromes on sister chromatids. These ectopic recombination events occur at nearly all Y-linked palindromes. Based on our findings, we propose that intrapalindrome sequence identity is maintained via noncrossover pathways of homologous recombination. DNA double-strand breaks that initiate these pathways can be alternatively resolved by crossing over between sister chromatids to form idicY chromosomes, with clinical consequences ranging from spermatogenic failure to sex reversal and Turner syndrome. Our observations imply that crossover and noncrossover pathways are active in nearly all Y-linked palindromes, exposing an Achilles' heel in the mechanism that preserves palindrome-borne genes.National Institutes of Health (U.S.)Howard Hughes Medical InstituteNetherlands Organization for Scientific ResearchUniversity of Amsterdam. Academic Medical CenterBoehringer Ingelheim (Fellowship
Vitamin B12 Deficiency Alters the Gut Microbiota in a Murine Model of Colitis
Purpose: Inflammatory bowel disease (IBD) refers to a spectrum of autoimmune diseases, which result in chronic intestinal inflammation. Previous findings suggest a role for diet, nutrition and dysbiosis of the gut microbiota in both the development and progression of the condition. Vitamin B12 is a key cofactor of methionine synthase and is produced solely by microbes. Previous work links increased levels of homocysteine, a substrate of methionine synthase, MetH, to IBD indicating a potential role for vitamin B12 deficiency in intestinal injury and inflammation. This study assessed the role of vitamin B12 in shaping the gut microbiota and determining responses to intestinal injury using a reproducible murine model of colitis.
Methods: The effects of vitamin B12 supplementation and deficiency were assessed in vivo; 3-week-old post-weanling C57Bl/6 mice were divided into three dietary treatment groups: (1) sufficient vitamin B12 (50 mg/Kg), (2) deficient vitamin B12 (0 mg/Kg) and (3) supplemented vitamin B12 (200 mg/Kg) for a period of 4 weeks. Intestinal injury was induced with 2% dextran sodium sulphate (DSS) via drinking water for 5 days. The impact of varying levels of dietary vitamin B12 on gut microbiota composition was assessed using 16S rRNA gene sequencing from fecal samples collected at day 0 and day 28 of the dietary intervention, and 7 days following induction of colitis on day 38, when blood and colonic tissues were also collected.
Results: No significant alterations were found in the gut microbiota composition of disease-free animals in response to dietary interventions. By contrast, after DSS-induced colitis, >30 genera were significantly altered in vitamin B12 deficient mice. Altered B12 levels produced no significant effect on composite disease-activity scores; however, administration of a B12 deficient diet resulted in reduced DSS-induced epithelial tissue damage.
Conclusions: Vitamin B12 supplementation does not alter the gut microbiota composition under healthy conditions, but does contribute to differential microbial responses and intestinal dysbiosis following the induction of experimental colitis
Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans
Peer reviewedPublisher PD
Self-affirmation improves music performance among performers high on the impulsivity dimension of sensation seeking
In the light of evidence that self-affirmation can mitigate the negative effects of stress on outcomes, this study tested whether a self-affirmation manipulation could improve undergraduate studentsâ achievement in a formal musical performance examination. The study also investigated the association between impulsivity and music performance and explored whether impulsivity moderated any impact of self-affirmation on exam performance. Methods: At baseline, participants provided demographic information and completed the UPPS-P Impulsive Behaviour Scale (short-form), which assesses five dimensions of impulsivity (negative and positive urgency, lack of premeditation, lack of perseverance, and sensation seeking). In the subsequent 14 days, participants (N = 65) completed either a self-affirmation manipulation or a control task, before reading a message about the impact of practice on music performance. Music performance was formally assessed 14 days later. Findings: Sensation seeking was the only dimension of impulsivity associated with exam performance, with participants high in sensation seeking receiving lower grades. Critically, self-affirmation promoted better music performance among those high in sensation seeking. Discussion: Self-affirmation may provide a useful intervention to augment the performance of musicians who would otherwise perform worse than their counterparts under formal evaluative circumstances, such as those high in sensation seeking
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Neuropsychiatric Symptoms and Expenditure on Complementary and Alternative Medicine
ObjectiveâNeuropsychiatric symptoms affect 37% of US adults. These symptoms are often refractory to standard therapies, and patients may consequently opt for complementary and alternative medicine therapies (CAM). We sought to determine the demand for CAM by those with neuropsychiatric symptoms compared to those without neuropsychiatric symptoms as measured by out-of-pocket expenditure. MethodâWe compared CAM expenditure between US adults with and without neuropsychiatric symptoms (n = 23,393) using the 2007 National Health Interview Survey. Symptoms included depression, anxiety, insomnia, attention deficits, headaches, excessive sleepiness, and memory loss. CAM was defined per guidelines from the National Institutes of Health as mind body therapies, biological therapies, manipulation therapies, or alternative medical systems. Expenditure on CAM by those without neuropsychiatric symptoms was compared to those with neuropsychiatric symptoms. ResultsâOf the adults surveyed, 37% had â„ 1 neuropsychiatric symptom and spent $ 14.8 billion out-of-pocket on CAM. Those with â„ 1 neuropsychiatric symptom were more likely than those without neuropsychiatric symptoms to spend on CAM (27.4% vs 20.3%, P < .001). Likelihood to spend on CAM increased with number of symptoms (27.2% with â„ 3 symptoms, P < .001). After adjustment was made for confounders using logistic regression, those with â„
Evaluating the cost-effectiveness of biologic treatments for psoriatic arthritis: : can we make better use of patient data registries?
The primary aim of this study is to explore the extent to which registry data may fulfill the evidence requirements of cost-effectiveness analysis (CEA) studies evaluating biologic therapies for the treatment of psoriatic arthritis (PsA), where trial data are lacking or insufficient. In addition, the paper aims to identify how future data collection in PsA registries might be better tailored to inform CEA research. A review of the literature was performed to identify existing registries containing PsA patients. Where possible, information was extracted on the design and characteristics of the registries. The registries were then appraised according to a set of criteria that was formulated based on the methods currently used to model PsA in the CEA literature. A review of the literature identified 21 potentially relevant registries from around the world containing patients with PsA. There was substantial variation regarding the extent to which the registries, as a whole, were useful for the purposes of CEA studies. There were also notable disparities found in terms of the accessibility of the registries to researchers. The critical review conducted in this study showed that all of the registries identified are potentially useful, at least in some degree, for the purposes of informing CEA studies in PsA. However, no individual registry on its own was found to meet all of the evidence requirements when considering how the disease has been modeled previously
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